Screening of honey bee pollen constituents against COVID-19: an emerging hot spot in targeting SARS-CoV-2-ACE-2 interactionArticle Published on 2023-03-012023-07-09 Journal: Natural Product Research [Category] COVID19(2023년), [키워드] ACE-2 cell entry process honey bee pollen natural products in silico studies. SARS-CoV-2 spike [DOI] 10.1080/14786419.2022.2092865 PMC 바로가기
Decrypting the cellular and molecular intricacies associated with COVID-19-induced chronic painReview Published on 2022-12-012023-07-10 Journal: Metabolic brain disease [Category] COVID19(2023년), [키워드] ACE-2 COVID-19 Cytokinetic storm headache IL-6 Pain. PGE2 [DOI] 10.1007/s11011-022-01048-8 PMC 바로가기 [Article Type] Review
Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cellsArticle Published on 2022-11-012022-11-15 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin Cell Cell culture cell membrane cells chain Combination combination treatment Course COVID-19 defend demonstrated experiment expressed expression Host IFN-γ immune defense immunocytochemistry in vitro data interferon-γ material membrane mRNA mRNA level observation primary culture Protein protein level reaction receptor RT-PCR SARS-CoV-2 shown supported Therapeutic benefit Thyrocytes Thyroid Thyroid. tissue treated Treatment up-regulate up-regulated up-regulating Vitamin D were measured would increase [DOI] 10.1007/s40618-022-01857-9 PMC 바로가기
Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated IndividualsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE2 ACE2 binding analyzed Angiotensin converting enzyme-2 Anti-RBD IgG Anti-spike anti-spike antibody anti-Spike IgG antibody binding blood collection BNT162b2 calculated collected Concentration correlated correlation correlation coefficient correlation coefficients COVID-19 COVID-19 antibody demonstrated dosing interval examined Fisher group groups IgG individual inhibition interval intervals labor-intensive measure mRNA mRNA-1273 vaccines Neutralizing antibodies neutralizing antibodies. neutralizing antibody Neutralizing antibody titer neutralizing antibody titers NTD Participants performed RBD Sample SARS-CoV-2 Secondary analyses Spearman correlation coefficient subgroup tested the median the vaccine titer vaccinated individual vaccination Vaccine vaccinee vaccinees Validity viral neutralization wild-type with COVID-19 women [DOI] 10.1128/spectrum.01315-22 PMC 바로가기
Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?Review Published on 2022-10-012022-10-06 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE-2 analyzed Angiotensin converting enzyme-2 B.1.1.529 catastrophic circulating contagious COVID-19 COVID-19 cases COVID-19 pandemic detrimental dissemination dominant Efficacy effort Evolution explained feasible feature FIVE Genetic hazard host receptor immune evasion immunization implication include Lineage Measures mechanism Mutation omicron Omicron variant other variant pandemic pharmacological physical Population prevalent strain raise RBD reported S-protein SARS-CoV-2 South Africa spike mutation Spread Sublineages surpassed Surveillance susceptible the receptor-binding domain the spike protein United Kingdom Vaccine vaccine effectiveness variant variants of concern variants of SARS-CoV-2 variants. viral entry VoC VOCs [DOI] 10.1016/j.biopha.2022.113522 PMC 바로가기 [Article Type] Review
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenalReview Published on 2022-09-062022-10-04 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, [키워드] 3CLpro 3CLpro inhibitors accelerated ACE-2 ACE2 antibody anticipated Antiviral effect approach benefit composed Conjugates conserved Coronaviruses COVID-19 COVID-19 pandemic COVID19 drug Drug discovery effort Evidence FDA approval In-vitro inhibitor Medicinal chemistry monoclonal antibodies peptide-based peptides plethora PLPro PLpro inhibitors Predictive model Prevent Proteases Protein pursuit RdRP RdRp inhibitors Replication reported required researcher S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants small molecule small molecule drug Small molecule inhibitors targets therapeutic option TMPRSS2 TMPRSS2 drug repurposing TMPRSS2 inhibitors Treatment vaccination vaccine platform Vaccines viral entry viral replication viral replication. [DOI] 10.1186/s12929-022-00847-6 PMC 바로가기 [Article Type] Review
The sex and gender dimensions of COVID-19: A narrative review of the potential underlying factorsReview article Published on 2022-09-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 ACE-2 receptor addition airway alcohol Biological difference cardiovascular diseases cells complex interplay coronavirus disease COVID-19 diabetes dimension discrepancy disorders downregulating Estrogen Evidence exhibited expression Factor Factors female females Gender Gender disparities health regulations Hormones immune response increase Infection involved kidney lung male Male sex males men men and women Mortality Multiple outcome outcomes progesterone protective role reduced risk risk factor Risk factors robust severe disease severity of COVID-19 Sex smoking Sociocultural effects statistically the SARS-CoV-2 viral infections virus with COVID-19 women [DOI] 10.1016/j.meegid.2022.105338 [Article Type] Review article
Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19COVID-19로 입원한 남성의 개선된 결과와 관련된 레닌-안지오텐신 시스템 경로 치료제Observational Study Published on 2022-09-012022-09-11 Journal: Critical Care Medicine [Category] 유전자 메커니즘, 임상, [키워드] ACE ACE inhibitor ACE inhibitors ACE-2 ACE2 gene acute COVID-19 acute COVID-19 illness acute respiratory syndrome acute respiratory syndrome coronavirus adjusted odds ratio Admission Analysis angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme ARB ARBs baseline baseline characteristics cohort of patient Comorbidities component components contribute coronavirus COVID-19 COVID-19 illness d -dimer determine downregulate dysregulation Effect explain female females hospital Hospitalized hospitalized patient hospitalized patients Improved include inhibitor inhibitors Interaction less male measurement Mortality multicenter Observational cohort study organ support outcome outcomes Patient plasma polymerase chain polymerase chain reaction pro-inflammatory Prospective RAS recorded Renin renin-angiotensin system response severe acute respiratory syndrome Coronavirus Sex Sex-related differences significant effect significantly significantly higher System Therapeutics Treatment Vasopressor vasopressors Ventilation with COVID-19 X chromosome [DOI] 10.1097/CCM.0000000000005589 PMC 바로가기 [Article Type] Observational Study
Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19Article Published on 2022-09-012022-11-15 Journal: American journal of physiology. Lung cellular and [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 ACE2 addition airway alveolar angiotensin-converting enzyme 2 anti-inflammatory effect Anti-inflammatory effects anti-inflammatory property antioxidant Antiviral Antiviral effect antiviral effects binding cell entry cleavage cleave Concentration COVID-19 cysteamine decrease determine disrupt drug drugs Effect effective functional hamster hemorrhage in vivo infected with SARS-CoV-2 Inflammation inhibit Injury intraperitoneally limit lung Lung inflammation Lung injury mechanism neutrophilic oxidative stress pseudovirus redox status reporter SARS-2-S SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike glycoprotein SARS-CoV-2 viruses significantly tested thiol drugs. thiol group viral infection virus infection [DOI] 10.1152/ajplung.00136.2022 PMC 바로가기